Results - 2gqnA

Structure of tRNA isopentenyltransferase

Localisation Expression of tRNA isopentenyltransferase

Generally, this enzyme is expressed in all tissue types since it is important that functional protein are synthesized in each of these tissues. Specifically, it is highly expressed in adipose tissues as well as oocytes. Relatively high amounts of this enzyme is expressed in prostate, adrenal gland, B-cells and trachea. The reason why tRNA-IPT are at higher concentrations in these tissues may reflect higher levels of protein synthesis.

Using the LOCATE program, it is found that this enzyme is concentrated in the nucleus of cells as a soluble, non-secreted protein in humans. As for mouse, this enzymes are found in the cytoplasm and mitochondria.

Domain and Structural Analysis

Structural Elements and Functional Binding Sites of tRNA isopentenyltransferase

-Residue Flexibility -Hydrophobicity LOCATE results show that this enzyme is soluble in nature; although a small part of the protein terminus is hydrophobic.

-Functional Sites Found By Pattern Search

Table 1 

-Functional Sites Found by Sequence Conservation In Structurally Related Proteins -Functional Sites Found by Structure Conservation In Structurally Related Proteins -Multiple Sequence Alignment

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