Functional analysis of 2ece

FUNCTIONAL analysis of SELENBP 1 (pdb 2ece)

The red coloured region is the region carrying Se, and it is evident that the Se is incorporated in an amino acid of the helix chain.(Pymol Image)

DaliLite: Structural Neighbours

Query: mol1A MOLECULE: 462AA LONG HYPOTHETICAL SELENIUM-BINDING PROTEIN;

Matches are sorted by Z-score. Similarities with a Z-score lower than 2 are spurious.

Summary

   No:  |Chain|   Z|    rmsd| lali| nres|  %id|  Description

  1:    |2ece-A |80.1  |0.0  |455   |455  |100   |MOLECULE: 462AA LONG HYPOTHETICAL SELENIUM-BINDING PROTEIN;          
  2:    |1ri6-A |32.6  |2.6  |314   |333  | 12   |MOLECULE: PUTATIVE ISOMERASE YBHE;                                   
  3:    |1jof-A |31.3  |2.9  |329   |365  |10   |MOLECULE: CARBOXY-CIS,CIS-MUCONATE CYCLASE;                          
  4:    |1l0q-C |30.3  |2.2  |286   |391  | 15   |MOLECULE: SURFACE LAYER PROTEIN;                                     
  5:    |1l0q-B |30.3  |2.2  |286   |391  | 15   |MOLECULE: SURFACE LAYER PROTEIN;                                     
  6:    |1l0q-A |30.3  |2.2  |286   |391  | 15   |MOLECULE: SURFACE LAYER PROTEIN;                                     
  7:    |1l0q-D |30.2  |2.2  |286   |391  | 15   |MOLECULE: SURFACE LAYER PROTEIN;                                     
  8:    |1qni-D |28.3  |2.8  |317   |572  | 11   |MOLECULE: NITROUS-OXIDE REDUCTASE;                                   
  9:    |1qni-F |28.0  |2.8  |317   |572  | 11   |MOLECULE: NITROUS-OXIDE REDUCTASE;                                   
 10:    |1fwx-D |28.0   |2.8  |316   |588  | 10   |MOLECULE: NITROUS OXIDE REDUCTASE;                                   
 11:    |1fwx-A |27.9  |2.9  |318   |591   |10   |MOLECULE: NITROUS OXIDE REDUCTASE;  
 21:    |1sq9-A |25.0  |3.0  |293   |378   |10   |MOLECULE: ANTIVIRAL PROTEIN SKI8; 
 23:    |2z2o-C |24.5  |2.6  |269   |299   |10   |MOLECULE: VIRGINIAMYCIN B LYASE;
 25:    |1yfq-A |24.4  |3.1  |287   |342   |11   |MOLECULE: CELL CYCLE ARREST PROTEIN BUB3;
 42:    |1pev-A |23.5  |2.9  |282   |610   | 9   |MOLECULE: ACTIN INTERACTING PROTEIN 1;
 159:   |1bpo-B |13.6  |4.1  |261   |493   | 8   |MOLECULE: CLATHRIN;
 277:   |1a12-B |9.3  |3.9  |235   |401    |8   |MOLECULE: REGULATOR OF CHROMOSOME CONDENSATION 1;

The above table shows some condensed Dali results. The proteins that might have direct carcinogenic effects via the immune system are highlighted. Most of the proteins that have structural similarity to SBP are highly involved in redox reactions,like the reductases.

WARNING! Given sequence appeared to be a soluble protein, no TM domains found!

Output format is the following:

1st line -> residue numeration

2nd line -> query amino acid sequence

3rd line -> trans-membrane domain prediction (T-TM region, N-soluble part)

     MAIVPFKRDPTFYPSPKMAMKAPPEDLAYVACLYTGTGINRADFIAVVDVNPKSETYSKI
    NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
                                                           
     VHKVELPYINDELHHFGWNACSSALCPNGKPNIERRFLIVPGLRSSRIYIIDTKPNPREP
     NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
                                                             
     KIIKVIEPEEVKKVSGYSRLHTVHCGPDAIYISALGNEEGEGPGGILMLDHYSFEPLGKW
     NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
                                                      
     EIDRGDQYLAYDFWWNLPNEVLVSSEWAVPNTIEDGLKLEHLKDRYGNRIHFWDLRKRKR
     NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
                                                       
     IHSLTLGEENRMALELRPLHDPTKLMGFINMVVSLKDLSSSIWLWFYEDGKWNAEKVIEI
     NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
                                                      
     PAEPLEGNLPEILKPFKAVPPLVTDIDISLDDKFLYLSLWGIGEVRQYDISNPFKPVLTG
     NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
                                                     
     KVKLGGIFHRADHPAGHKLTGAPQMLEISRDGRRVYVTNSLYSTWDNQFYPEGLKGWMVK
     NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
                                  
     LNANPSGGLEIDKEFFVDFGEARSHQVRLSGGDASSDSYCYP
     NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN

SABLE server results indicating that SBP is a soluble protein.Therefore, little is to be expected for it to be membrane spanning molecule, but it might be useful in the cytosol.

Back to results Results 2ece

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