Function: Difference between revisions

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most likely function is N-acetylneuraminic acid phosphatase.
most likely function is N-acetylneuraminic acid phosphatase.


The haloalkanoate dehalogenase superfamily (HADSF) is one of the largest and most ubiquitous enzyme families identified to date, with over 3,000 members in organisms ranging from bacteria to humans. Remarkable diversity of chemistry and function has emerged through evolution of the HAD catalytic scaffold. Despite the name, the dehalogenases, which catalyze carbon group transfer, represent a minute fraction of the family. All other known catalytic activities are directed at phosphoryl transfer. Numerous proteins from the HADSF are found in each organism (29 in E. coli and 58 in humans, for example) where they perform a diverse collection of novel physiological functions in primary and secondary metabolism, membrane transport, signal transduction, and nucleic acid repair. http://biophysics.bumc.bu.edu/faculty/allen/allenpage/had.htm
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Revision as of 06:47, 15 May 2007

Proposed Functions

  • Hydrolase Activity
  • Magnesium Ion Binding
  • N-acylneuraminate-9-phosphatase Activity
  • Phosphoglycolate Phosphatase Activity


1. Hydrolase Activity

2. Magnesium Ion Binding

3. N-acylneuraminate-9-phosphatase Activity

4. Phosphoglycolate Phosphatase Activity


Table of functions
Catalytic activity N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate
Cofactor Magnesium (By similarity)
Enzyme regulation Inhibited by vanadate and calcium (By similarity)
Pathway Carbohydrate metabolism; aminosugar metabolism
Similarity Belongs to the haloacid dehalogenase-like hydrolase superfamily. NANP family



GO Terms

Polymer: haloacid dehalogenase-like hydrolase domain containing 4

Molecular Function: None

Biological Process: None

Cellular Component: None





info

N-acetylneuraminic acid phosphatase

Homologous to mouse (Mus musculus)

Haloacid Dehalogenase Like Hydrolase Domain Containing 4

Classified as Hydrolase

Infomation on ProFunc (useful 2gfhA)

Information on PDBsum (2gfh)

From FASTA most likely function is N-acetylneuraminic acid phosphatase.

The haloalkanoate dehalogenase superfamily (HADSF) is one of the largest and most ubiquitous enzyme families identified to date, with over 3,000 members in organisms ranging from bacteria to humans. Remarkable diversity of chemistry and function has emerged through evolution of the HAD catalytic scaffold. Despite the name, the dehalogenases, which catalyze carbon group transfer, represent a minute fraction of the family. All other known catalytic activities are directed at phosphoryl transfer. Numerous proteins from the HADSF are found in each organism (29 in E. coli and 58 in humans, for example) where they perform a diverse collection of novel physiological functions in primary and secondary metabolism, membrane transport, signal transduction, and nucleic acid repair. http://biophysics.bumc.bu.edu/faculty/allen/allenpage/had.htm


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