DHRS1 Introduction

Introduction.

Short-chain Dehydrogenase/Reductase (SDR) is a large protein family currently numbering about 2000 members (Kallberg et al. 2002). It also goes by the alternative name of the tyrosine-dependent oxidoreductase protein family (Edgar, 2002) because of their conserved tyrosine residue at position 152. Protein families are defined by their structural and functional similarities and generally have evolved from a common ancestor. SDR proteins have a length of about 250 amino acids (aa) and show approximately 15-30% sequence similarity/identity. This is relatively low when compared to other families. Despite this, members still have conserved structural folds and a conserved function.

Dehydrogenase/Reductase member 1 (DHRS1) is one member of the SDR family

Often, the term protein family is used interchangeably with gene family,

The objective of this project is to find relative functional and structural information on DHRS1 in order to make an appropriate conclusion on its role organism function.

Edgar, A. (2002) Molecular cloning and tissue distribution of mammalian L-threonine 3-dehydrogenases. BMC Biochemistry (3) 19. Published Online at http://www.biomedcentral.com/1471-2091/3/19

Kallberg, Y. Oppermann, U. Jörnvall, H. and Persson, B. (2002) Short-chain Dehydrogenase/Reductase (SDR) Relationships: A Large Family With Eight Clusters Common to Human, Animal, and Plant Genomes. Protein Science (11) 636-641. http://www.proteinscience.org/cgi/content/full/11/3/636