Arylformamidase Introduction: Difference between revisions
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'Arylformamidase' heralds from Silibacter sp. TM1040, a member of the Roseobacter clade of alpha-proteobacteria. It was first isolated as part of an investigation into the role of bacteria in the physiology and toxigenesis of the dinoflagellate Pfiestera piscicida. Silicibacter sp. TM1040 has been found necessary for the survival of this organism. Most interestingly, the bacteria is able to demethylate the dinoflagellate secondary metabolite dimethylsulfoniopropionate (DMSP) to methylmercaptopropionic acid (MMPA). DMSP is the major source of organic sulphur in the world’s oceans, forming a major part of the global sulphur cycle. | 'Arylformamidase' heralds from Silibacter sp. TM1040, a member of the Roseobacter clade of alpha-proteobacteria. It was first isolated as part of an investigation into the role of bacteria in the physiology and toxigenesis of the dinoflagellate Pfiestera piscicida. Silicibacter sp. TM1040 has been found necessary for the survival of this organism. Most interestingly, the bacteria is able to demethylate the dinoflagellate secondary metabolite dimethylsulfoniopropionate (DMSP) to methylmercaptopropionic acid (MMPA). DMSP is the major source of organic sulphur in the world’s oceans, forming a major part of the global sulphur cycle. | ||
Upon crystallisation, 2pbl formed a tetramer structure. However, structures formed upon crystalisation do not always denote the functional form of a protein which can exist as a dimer or oligomer as well. In fact, such forms may have been evolutionary selected for to confer features such as thermostability (Byun 2007). By examining the crystal structure and … , we have attempted to deduce the functional form of 2pbl. | |||
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Revision as of 09:15, 3 June 2008
why it was chosen for structural determination
how its annotation arrived at 'arylformamidase
information from pdb - structure details, etc... (perhaps picture)
paragraph on silicibacter sp tm1040 - evolutionary info (where it fits in) (diagram)
'Arylformamidase' heralds from Silibacter sp. TM1040, a member of the Roseobacter clade of alpha-proteobacteria. It was first isolated as part of an investigation into the role of bacteria in the physiology and toxigenesis of the dinoflagellate Pfiestera piscicida. Silicibacter sp. TM1040 has been found necessary for the survival of this organism. Most interestingly, the bacteria is able to demethylate the dinoflagellate secondary metabolite dimethylsulfoniopropionate (DMSP) to methylmercaptopropionic acid (MMPA). DMSP is the major source of organic sulphur in the world’s oceans, forming a major part of the global sulphur cycle.
Upon crystallisation, 2pbl formed a tetramer structure. However, structures formed upon crystalisation do not always denote the functional form of a protein which can exist as a dimer or oligomer as well. In fact, such forms may have been evolutionary selected for to confer features such as thermostability (Byun 2007). By examining the crystal structure and … , we have attempted to deduce the functional form of 2pbl.
