Protein Evolution
Conservation of MIF4GD in Eutheria (Placental Mammals)
Conservation of the protein structure in many organisms, including Pan troglodytes (chimpanzee), Mus musculus (house mouse), Rattus norvegicus (brown rat), Bos taurus (domestic cow) and Danio rerio (zebrafish).
SUMMARY
The protein sequence was transformed into FASTA format
Using Command Prompt and the CD, BLASTed the protein sequence. First used a vertebrate_other database (which produced only 12 significant results), before was finally able to access the nonredundant database with 68 homologous matching sequences and several different species including Danio rerio, Homo sapiens, Mus musculus, Bos taurus, Xenopus tropicalis, Rattus norvegicus, Xenopus laevis, Macaca fascicularis (long-tailed macaque), Canis familiaris, Pan troglodytes, Drosophila melangaster, Drosophila pseudoobscura, Aedes aegypti (mosquito), Tetraodon nigroviridis (green spotted pufferfish) and Oryza sativa (rice).
The protein seems to be conserved throughout the animals and is found in plants. Must have a quite important function. Hopefully when the phylogenetic tree is constructed, will get more insight into the evolution of MIF46 domain containing protein.
File that show the significant sequences obtained from the non-redundant database.
