Structure of 1zkd
From MDWiki
Jump to navigationJump to search
Result from DALI shows proteins that are similar to the 1zkd. They are 2ex4 and 1im8. These 2 proteins matches 1zkd the most according to DALI. The pictures below shows the structures of the proteins related comparing to 1zkd.
Sequence
MIDQTALATEIKRLIKAAGPMPVWRYMELCLGHPEHGYYVTRDPLGREGDFTTSPEISQMFGELLGLWSASVWKAADEPQ TLRLIEIGPGRGTMMADALRALRVLPILYQSLSVHLVEINPVLRQKQQTLLAGIRNIHWHDSFEDVPEGPAVILANEYFD VLPIHQAIKRETGWHERVIEIGASGELVFGVAADPIPGFEALLPPLARLSPPGAVFEWRPDTEILKIASRVRDQGGAALI IDYGHLRSDVGDTFQAIASHSYADPLQHPGRADLTAHVDFDALGRAAESIGARAHGPVTQGAFLKRLGIETRALSLMAKA TPQVSEDIAGALQRLTGEGRGAMGSMFKVIGVSDPKIETLVALSDDTDREAERRQGTHGLEHHHHHH
Information on 1zkd
Located on 2p22.2 on human chromosome with 441 aa
Located on 17E3 on mouse chromosome with 436 aa
Alignment with 2ex4 1ZKD:A 24/25 WRYXELCLGHPEHGYYV--TRDPLGREGDFTTSPEISQXFGELLGLWSASVWKAAD-EPQ 2EX4:A 24/7 IEDEKQFYS----KAKTYWKQIPPTVDGMLGGYGHISSIDINSSRKFLQRFLREGPNKTG 1ZKD:A 81/82 TLRLIEIGPGRGTXXADALRALRVLPILYQSLSVHLVEINPVLRQKQQTLLAGI-RNIHW 2EX4:A 80/64 TSCALDCGAGIGRITKRLLLPL--------FREVDMVDITEDFLVQAKTYLGEEGKRVRN 1ZKD:A 140/141 HD-----SFEDVPEGPAVILANEYFDVLPIHQAIKRETGWHERVIEIGASGELVFGVAAD 2EX4:A 132/116 YFCCGLQDFTPEPDSYDVIWIQWVIGHLT------------------------------- 1ZKD:A 195/196 PIPGFEALLPPLARLSPPGAVFEWRP--DTEILKIASRVRDQGGAALIIDYG--HLRSDV 2EX4:A 161/145 ------------------------DQHLAEFLRRCKGSL-RPNGIIVIKDNMAQE----- 1ZKD:A 251/252 GDTFQAIASHSYADPLQHPGRADLTAHV---DFDALGRAAESIGARAHGPVTQG 2EX4:A 191/175 GVILDD---------------VDSSVCRDLDVVRRIICSAG---LSLLAEERQE
Alignment with 1im8 1ZKD:A 59/60 QXFGELLGLWSASVWKAADEPQTLRLIEIGPGRGTXXADALRALRVLPILYQSLSVHLVE 1IM8:A 42/40 SNIITAIGXLAERFV-----TADSNVYDLGCSRGAATLSARRNI-----NQPNVKIIGID 1ZKD:A 119/120 INPVLRQKQQTLLAGI---RNIHWHD--SFEDVPEGPAVILANEYFDVLPIHQAIKRETG 1IM8:A 92/90 NSQPXVERCRQHIAAYHSEIPVEILCNDIRHVEIKNASXVILNFTLQFLP---------- 1ZKD:A 174/175 WHERVIEIGASGELVFGVAADPIPGFEALLPPLARLSPPGAVFEWRP--DTEILKIASRV 1IM8:A 142/140 ---------------------------------------------PEDRIALLTKIYEGL 1ZKD:A 232/233 RDQG--GAALIIDYG 1IM8:A 157/155 ---NPNGVLVLSEKF
Most probably a methyltransferase as most of the matches from DALI are transferase
S-ADENOSYL-L-HOMOCYSTEINE - Structure that Identify Transferase
DALI Results
SUMMARY: PDB/chain identifiers and structural alignment statistics
NR. STRID1 STRID2 Z RMSD LALI LSEQ2 %IDE REVERS PERMUT NFRAG TOPO PROTEIN 1: 3027-A 1zkd-A 56.8 0.0 349 349 100 0 0 1 S STRUCTURAL GENOMICS, UNKNOWN FUNCTION duf185 (rhodops 2: 3027-A 2ex4-A 11.7 3.0 185 221 12 0 0 22 S TRANSFERASE adrenal gland protein ad-003 (homo sapien 3: 3027-A 1im8-A 11.6 3.2 178 225 10 0 0 18 S TRANSFERASE yeco (methyltransferase, hypothetical pro 4: 3027-A 2gb4-A 10.8 3.3 184 231 13 0 0 19 S TRANSFERASE thiopurine s-methyltransferase (thiopurine 5: 3027-A 2fk7-A 10.7 3.8 186 277 14 0 0 19 S TRANSFERASE methoxy mycolic acid synthase 4 (mycobact 6: 3027-A 2ob1-A 10.2 3.9 196 319 9 0 0 23 S TRANSFERASE leucine carboxyl methyltransferase 1 (prot 7: 3027-A 2f8l-A 10.0 3.7 182 318 8 0 0 22 S STRUCTURAL GENOMICS, UNKNOWN FUNCTION hypothetical pro 8: 3027-A 2avn-A 10.0 3.7 183 242 11 0 0 20 S STRUCTURAL GENOMICS, UNKNOWN FUNCTION ubiquinoneMENAQU 9: 3027-A 2bzg-A 9.9 3.4 182 226 13 0 0 20 S TRANSFERASE thiopurine s-methyltransferase (thiopurine 10: 3027-A 2aot-A 9.8 4.3 182 285 13 0 0 23 S TRANSFERASE histamine n-methyltransferase (hmt) (homo 11: 3027-A 2p8j-A 9.7 3.4 168 203 10 0 0 16 S TRANSFERASE s-adenosylmethionine-dependent methyltrans 12: 3027-A 1vl5-A 9.7 3.3 167 225 9 0 0 18 S STRUCTURAL GENOMICS, UNKNOWN FUNCTION unknown conserve 13: 3027-A 1hnn-A 9.7 3.4 183 261 13 0 0 18 S TRANSFERASE phenylethanolamine n-methyltransferase (p 14: 3027-A 1m6e-X 9.6 3.6 206 359 9 0 0 27 S TRANSFERASE s-adenosyl-l-methionnine:salicylic acid ca 15: 3027-A 2fay-A 9.5 3.9 178 274 14 0 0 21 S 16: 3027-A 2h00-A 9.2 2.9 158 225 9 0 0 18 S TRANSFERASE methyltransferase 10 domain containing pro 17: 3027-A 1wy7-A 9.2 3.1 155 195 13 0 0 15 S TRANSFERASE hypothetical protein ph1948 (pyrococcus h 18: 3027-A 1m6y-A 8.8 4.3 156 289 10 0 0 19 S TRANSFERASE s-adenosyl-methyltransferase mraw (thermo 19: 3027-A 1i9g-A 8.7 3.0 149 264 9 0 0 15 S TRANSFERASE hypothetical protein rv2118c (mycobacter 20: 3027-A 1zq9-A 8.6 3.2 144 278 16 0 0 19 S TRANSFERASE probable dimethyladenosine transferase (s-
Pfam Results
DUF185: domain 1 of 1, from 64 to 299: score 227.1, E = 3.9e-65
*->alArwllveykllgyPYadlnlvElGaGrGtaielmsdlLryiarlv
+l++w + ++k+ ++P l+l E+G+GrGt +m+d+Lr+ r+
query 64 LLGLWSASVWKAADEP-QTLRLIEIGPGRGT---MMADALRA-LRVL 105
PdvyartryylvEiSprLaarQketLapkvaplGhdskveieatdlsglv
P +y+ ++++lvEi+p L+++Q++ La ++ ++
query 106 PILYQSLSVHLVEINPVLRQKQQTLLA-----------------GIR-NI 137
rWhdasileedPdgvptvliaNEVlDalPHDlvrfdkrgggwyErhVlvd
Whd s +e++P+g p v++aNE +D lP +++ +kr+ gw+Er V ++
query 138 HWHD-S-FEDVPEG-PAVILANEYFDVLP--IHQAIKRETGWHER-V-IE 180
ldgdfrlvysqeldplaglaltlreaaldPVKstkklvpsalskllpkll
+ ++lv+++++dp g+ ++l
query 181 IGASGELVFGVAADPIPGFEAL------------------------LPPL 206
ppaeevgygtEvYsParllellqalaerLpahrGrlLaiDYGhlaseyyh
+ +g+++E+ P e+l+++ + + +G++L+iDYGhl+s
query 207 ARLSPPGAVFEW-RPDT--EILKIASRVRD-QGGAALIIDYGHLRSD--- 249
prrksalaaemfngtllqayrqhahddpltnpssllVlyStvaqGlaDiT
g+++qa+ h + dpl +p G+aD+T
query 250 ------------VGDTFQAIASHSYADPLQHP------------GRADLT 275
ahVDFtalaradqyqtaakaagdlkvlgvet<-*
ahVDF+al +aa +g + + g+ t
query 276 AHVDFDALG------RAAESIG-ARAHGPVT 299
