Pyridoxal Phosphatase Abstract

Pyridoxal (pyridoxine, vitamin B6) Phosphatase, otherwise known as PLP (or PDXP, in certain cases), is defined as the metabolically active form of the water-soluble Vitamin B6. Its functions involve: acting as a cofactor in many reactions of amino acid metabolism, gluconeogenesis and lipid metabolism.

Pyridoxal Phosphatase is an enzyme that catalyses the reaction:

                       Pyridoxal 5'-phosphate + H2O  pyridoxal + phosphate

Based on the provided PDB ID (2cfsA), evolutionary, structural and functional studies were carried out with the ultimate aim of further characterizing 2cfsA.