3bsqA Abstract

Sulfatases are hydrolytic enzymes, which cleave sulfuric ester bonds of their substrate. Sulfatases show highly conserved sequence feteures, especially in in the N-terminal region where the catalytic site is found. Arylsulfatase K is a water soluble enzyme found in endoplasmic retuculums (ER) of the cell. Structural studies show highly conserved features in ASK N-terminus with steroid sulfatase (STS) N-terminal catalytic site.