Pyridoxal Phosphatase function

General Annotation

Fig 17. General annotation of Pyridoxal Phosphatase. Picture courtesy of UniProt

Known Functions

Amino Acid Metabolism

- transamination

- transsulfuration

- selenoamino acid metabolism

- conversion of typtophan to niacin.

Gluconeogenesis

- Catalyse transamination reactions for gluconeogenesis.

- Coenzyme for glycogen phosphorylase, which catalyse glycogenolysis.

Neurotransmitter Synthesis

- Coenzyme for Pyridoxal phosphate-dependent enzymes, which catalyses the biosynthesis of serotonin, epinephrine, norepinephrine and gamma-aminobutyric acid(The four important neurotranmsitters).

Histamine Synthesis

- Metabolism of histamine.

Hemoglobin Synthesis and Function

- Synthesis of heme

- Binds to two sites on hemoglobin, enhancing the oxygen binding of hemoglobin.

Gene Expression

- Increases or decreases the expression of certain genes.

Sequence homology

Fig 18. Results from FASTA showing five highly related enzymes to 2cfsA

Structural Similarities

Fig 19. Search results using Interpro for similar protein structure based on motifs.

Location of Gene on Genome

Fig 20. Gene location results from Profunc showing two neighbouring genes of 2cfsA with very different sequence but similar function.

Functional Expression in Tissue

Fig 21. Tissue specific expression of the human PLP phosphatase mRNA. The human multiple tissue expression array was hybridized with human PLP phosphatase-specific DNA probe. Tissue sources for the RNA are indicated below the dot.

Protein-Protein Interactions

Fig 22. Diagram on protein-protein interaction of 2cfsA.

Functional Prediction:

Cofactor of HSPD1 and play a role in protein folding.

Coenzyme for asparagine synthetase by interacting with TS11.

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